oxidative stress

Background: Intense physical activity increases the production of reactive oxygen species in vital tissues such as the liver and causes oxidative stress. Aim: This study investigates the effect of high-intensity interval training and intense endurance training on oxidative stress of liver tissue in immature male rats during puberty. Materials and Methods: A total of 24 male Wistar rats (aged= 22 days, weight= 60±0.63 g), after one week of acclimatization, were divided randomly into three groups: control, IET, and HIIT. Rats were subjected to a four-week training on an animal treadmill. The effects of training treatment in rat liver were investigated by assaying oxidative stress biomarkers. Results: Comparing to control group, in both training groups significantly lower Malondialdehyde (MDA) was seen (( P (IET)= 0.016/ P (HIIT)= 0.020). However, there were no statistical differences in Glutathione Peroxidase (GPX) ( P = 0.463) and total antioxidant capacity (TAC) activity levels ( P = 0.194) among groups. HIIT training significantly increased superoxide dismutase (SOD) ( P = 0.040) and catalase enzyme (CAT) levels ( P = 0.007). IET and HIIT had significantly increased endurance performance (both: P = 0.001). Conclusion: Both training intensities did not lead to an increase in oxidative stress and can be used during puberty.

Purpose: Haematological, hormonal, biochemical and physical performance parameters were altered after long-term soccer training in professional soccer players. These alterations can be influenced by different contextual factors such as playing surface, training load, duration of training and competition. The purpose of this study was to investigate the changes in the haematological, inflammatory, antioxidant and physical performance of beach soccer players during the competitive season of the beach soccer. Method: The study examined 15 elite beach soccer players in Iranian beach soccer primer league (age 24.64 ± 4.01 y, weight 75.08 ± 8.15 kg, height 181.00 ± 5.17 cm, body mass index 22.76 ± 2.36) from the pre-season, mid-season and end-season. Measurements of haematological, inflammatory, antioxidants indices and aerobic / anaerobic power were repeated in the pre-season, mid-season and end-season. Repeated-measures analysis of variance was used to examine indicators change during league season. Results: Significant decrease in SOD (p = 0.001), TAC (p = 0.043) and anaerobic power (p ≤ 0.048) and significant increase in GPx (p = 0.001), ALT (p = 0.022) was observed from pre-season to the end of the season. LDH levels showed a significant increase in the mid-season compared to the pre-season (p = 0.042) and a significant decrease at the end of the season compared to the mid-season(p = 0.014). However, no significant changes were observed in other indices during the competition season(p ≥ 0.05). Conclusions: It is suggested that some physical and physiological fatigue markers ar increase during mid-season. Therefore, beach soccer players may be  monitored  continuously during the competition season in order to be able to provide the best training, nutrition and recovery systems for performance optimization. Coaches may use the interplay between biomarker alterations and physical performance changes to better manage workload and monitor fatigue during beach soccer training and competition.

The first report showing that long-term endurance exercise increases oxidative stress in humans was published more than 4 decades ago. Since this discovery, many subsequent studies have confirmed the fact that muscle activity increases the production of reactive oxygen species (ROS) and leads to oxidative stress in multiple tissues, including blood and skeletal muscle. Although several tissues may contribute to exercise-induced ROS production, muscle contractions are predicted to stimulate ROS production in active muscle fibers, and skeletal muscle is the major source of ROS production during exercise. This contraction-induced ROS production is associated with 1. oxidant damage in several tissues (eg, increased protein oxidation and lipid peroxidation), 2. accelerated muscle fatigue, and 3. activation of biochemical signaling pathways leading to adaptation. Exercise helps in tight muscle fibers, it is related. While our understanding of exercise and oxidative stress has advanced rapidly over the past decades, questions remain as to whether exercise-induced increased ROS production is beneficial or detrimental to health. This review addresses this issue by discussing the site(s) of oxidant production during exercise and detailing the health consequences of exercise-induced ROS production.

Background: Cardiovascular disease is a significant contributor to mortality in diabetic patients. Despite the potential benefits of concomitant and complementary training in diabetic patients, there is a paucity of evidence in this area.Aim: The objective of this study was to investigate the effect of aerobic training in conjunction with a hydroalcoholic extract of the fruit of Qaraqat on superoxide dismutase, glutathione peroxidase, total antioxidant capacity, and malondialdehyde in the heart tissue of male rats with type 2 diabetes.Materials and Methods: 24 male rats aged 8 weeks were diabetic with a high-fat diet (60%) and streptozotocin injection. They were randomly divided into four groups: (1) aerobic training (AT), (2) supplementation (Sup), (3) Aerobic training+ supplement (AT+Sup), and (4) diabetes control (Con). The training protocol included running on a treadmill at a speed of 5-24 m/min for 10-60 min, according to the principle of overload. Glucose, insulin, insulin resistance, and MDA, TAC, GPX, and SOD of heart tissue were measured. Statistical tests of two-way variance and post hoc Bonferroni were used using SPSS software at a significance level of P<0.005.Results A significant decrease in glucose levels, insulin resistance, and MDA (P<0.005) was observed in the intervention groups following eight weeks of training and supplement intervention, in comparison to the Con group. Also, the amount of insulin in Sup and AT+Sup groups exhibited a notable decline in comparison to Con and AT groups (P<0.005), as well as a substantial increase in the levels of SOD (P=0.001) and GPx (P<0.005), and TAC (P<0.005) was observed.Conclusion: Diabetes is associated with elevated MDA levels, which are reduced by aerobic training and supplementation. Furthermore, the administration of a training intervention and the utilization of a supplement have been demonstrated to elevate the levels of SOD, TAC, and GPx.