In recent years, stability in the security environment of Central Asia and the Caucasus has consistent-ly faced increasing complexities and challenges. Nationalistic tendencies in this region, presence of crises, emergence of internal challenges, weaknesses in nation-building, and the entry of foreign powers have added complexity to the region's security environment. Considering the competition of regional and trans-regional powers and their pursuit of interests in the South Caucasus region, the events in Karabakh in 2020 will not be the last one in this region. This region is always prone to events and crises. Iran must play a role in resolving conflicts in the South Caucasus region by main-taining a neutral yet more active policy than in the past. By establishing an independent mechanism, Iran can pursue its national interests in this region by leveraging existing opportunities. This qualita-tive research article uses an explanatory method to evaluate Iran's foreign policy in the face of region-al crises (such as the Karabakh war) based on the realism model of Morgenthau. It examines Iran's foreign policy approach to recent conflicts in the region and analyzes the role of influential regional and international factors, as well as geopolitical and geostrategic factors, shaping Iran's foreign poli-cy.