This study is practical in terms of its objectives, and this study aims to provide a comprehensive picture of the online teaching-learning process in Iranian service organizations (non-educational). This research methodology applied a quantitative approach in its data collection method. In the first part, using a systematic approach and documentary study, 870 related research about e-learning at non-academic organizations were identified. Then, formerly after being studied and analyzed based on the criteria such as the research title and abstract, finally, 32 cases were selected and analyzed. In order to determine the research validity have been used the instrument of the Basic Critical Appraisal Skills Program of Glyn et al. (2006) and to examine the reliability, the method of agreement between the two coders was used and confirmed at a kappa value of 731%. The results indicate that the most critical issues regarding the online teaching and learning system in non-academic organizations are the feasibility study and implementation of this method at the mentioned institutions. Furthermore, the systematic review findings also identified five critical challenges of the e-learning system. Therefore, the research results indicate that for implementing the online teaching-learning system, first, it is necessary to identify the challenges such as; challenges related to critical stakeholders, organization, pedagogy, technology, and support system.
