The relationship between the United States and the Islamic Republic of Iran has been a confrontational one in the past four decades and been influenced by the nature of the Islamic Revolution and its derived system. After the collapse of the Soviet Union, the United States tried to expand its ideals and structure of the desired order by using the power components in international system as a hegemonic power. However, Iran generally considers the US hegemony as a special type of domination and given the nature of the Islamic Republic of Iran with a unique ideological discourse, the resistance against the domination hegemony is necessary and therefore counter-hegemonic strategies and policies have always been Iranian policy priorities. This article aims to investigate the relationships between the two countries by using descriptive-analytical method in the framework of Neo-Gramscianism and in the hegemony power and counter-hegemony forms. The findings of the article show that in order to maintain its position of hegemony, the US has applied policies such as the coercive diplomacy, the soft warfare, de-legitimization of Iran and legitimization of the use of pressure through the international institutions against the country. In response Iran has tried to confront the US hegemonic position by adopting self-reliance policies, by making alliances and coalitions as well as pursuing independent political discourse in international system.
