Iran and Ethiopia have had bilateral relations for almost two thousand years. These relations were accompanied by cultural exchanges among the people, resulting in the acceptance of both nation’s cultural elements by the other. A thorough knowledge of these cultural exchanges is not only important in understanding the history of the bilateral relations between the two countries; it would also be helpful in planning future relations between Iran and Ethiopia. Therefore, this paper aims to study the important subject of “cultural exchanges between Iran and Ethiopia” through an analysis of the way in which each nation has culturally influenced the other. Based on Lahsaeizadeh’s theory of “Cultural Exchange between Different Ethnic Groups”, and through a meticulous observation of Iran-Ethiopia relations throughout history via library and field research, this paper attempts to examines the bilateral cultural influence of one nation on the other. The analysis of diverse historical documents as well as comprehensive field research indicate that while both nations have culturally influenced each other, it was the Iranian culture that had mostly influenced the Ethiopian culture for centuries in the field of language, architecture, religion and music. The reason for this strong influence is mainly the wider dominion of the Iranian civilization and culture.