Background: With the rapid digital transformation across the African continent, ensuring the protection of personal data through effective regulatory frameworks is crucial. Key regulations, including Nigeria’s Data Protection Regulation (NDPR) and the African Union’s Convention on Cyber Security and Personal Data Protection, have been enacted to address growing concerns about data privacy and cybersecurity.Aims: This literature review critically examines the impact of data privacy regulations on cybersecurity practices in Nigeria and across Africa, focusing on empirical studies that highlight the interplay between regulation enforcement and cybersecurity outcomes.Methodology: This review synthesizes empirical studies that explore the effectiveness of these regulations in improving cybersecurity practices in both public and private sectors.Results: Empirical research from Nigeria indicates that while the NDPR has led to some positive changes in organizational data protection strategies, challenges in enforcement, resource allocation, and awareness continue to hinder its full impact. Studies reveal that small to medium enterprises (SMEs) face difficulties in complying with the regulations due to a lack of capacity and knowledge. Similarly, research across several African countries shows a significant gap in both the implementation of data privacy laws and the cybersecurity measures required to mitigate emerging threats, such as ransomware and data breaches. Furthermore, empirical evidence highlights that varying levels of regulatory enforcement across the continent result in inconsistent cybersecurity practices, leading to vulnerabilities in the digital infrastructure. The review also explores empirical findings on the socio-economic and political barriers that affect the successful enforcement of data privacy regulations, with particular focus on limited technical expertise, political instability, and insufficient resources for regulatory bodies. Additionally, studies suggest that there is a growing need for cross-border collaboration and capacity building to bridge the regulatory gaps and improve overall cybersecurity resilience.Conclusion: Empirical evidence underscores the need for stronger regulatory frameworks and greater cooperation across African nations to enhance the protection of personal data and fortify cybersecurity practices across the region. Recommendations for future policy development are provided, based on the insights gained from existing empirical studies.