The Islamic awakening evolutions in the Middle East have changed the regional discipline in different aspects and affected the policies of regional and trans-regional actors since 2011. Meanwhile, the USA, which defined widespread interest in the region since the Second World War, encountered with the worst crisis than any other state. The present study investigated the USA interests in the Middle East and tested the effects of Islamic awakening on these interests. The main question of this study was the interaction and strategy of the USA in the Middle East for Islamic awakening. The result of this study indicated that the USA has put the measures such as direct military intervention and apparent changes in the ruling elite on its agenda to manage the military presence in the region and target countries, avoid reliance on one union, promote the secular Islamist model, have proximity to civil society and Islamists in the region, strengthen the human rights discourse and advance the process of reconciliation, and manage the challenges posed by the rise of Islamic awakening in the region in the long term.
