Objective: This study investigates the different motives and substance use risk profile in opium and methamphetamine use. Method: The statistical sample includes Seventy-eight individuals with substance use history referred to drop-in center (DIC) that completed research instruments including demographic information (researcher-made questionnaire), substance use motives (Hecimovic, Barrett, Darredeau, and Stewart, 2014), and substance use risk profile scale (Woicik et al., 2009). Multivariate analysis of variance utilized for data analysis based on SPSS-24. Results: The results of the MANOVA indicated that availability, relaxation, enjoying, and sexual motives are significantly higher in individuals using methamphetamine. Also, the results of the substance use risk profile represent that there are significant differences in anxiety sensitivity, sensation-seeking, and impulsivity in opium and methamphetamine use. Conclusions: Findings indicate the important role of motives and substance use risk profile in the tendency to the different types of substances. These various motives and personality risk factors should be considered in educational settings and psychological treatment for different types of substance use, especially opiate or stimulating substances.
