This research explores gender differences in motivations and gratifications related to playing video games such as The Sims. We analyzed both men’ and women’ differences in game related motivations and gratifications to identify which factors make a game more gratifying for a specific gender of players. We conducted in-depth interviews with 18 male players and 20 female players of The Sims. We also analyzed online forums of The Sims. We found that main gratifying factors related to game-playing experience include appearance, character, storyline, control and complexity, fantasy and social interaction. The findings propose that game researchers with the uses and gratifications theoretical framework should consider the importance of including game features as gratifying factors in their questionnaires. Finally, we have provided implications for future research about gender differences in motivations and gratifications based on uses and gratifications theory.