This study aims to determine whether the perceived ease of use and perceived usefulness can significantly predict the students’ intention to use video conferencing applications in an online classroom. This study utilized a descriptive predictive quantitative research design. This study used the survey questionnaires adopted from the study of Salloum et al. (2019). The researchers conducted an online survey using Google form for over a month. Out of 153 target respondents, 130 responded to the survey questionnaire. Linear regression was initiated using JASP 0.16.0.0. The findings revealed that the two variables perceived ease of use and perceived usefulness can both significantly predict the students’ intention to use video conferencing applications in an online classroom. The results further showed that the perceived ease of use can better predict the students’ intention to use video conferencing applications in an online classroom as compared to perceived usefulness. The findings imply that video conferencing applications used in the teaching and learning process should be user-friendly and pedagogically relevant to support students’ desire to use video conferencing applications.