Medical practitioners’ ethnocentric orientations and English language skills contribute to the success or failure of intercultural communication in the context of health care. The present study aims to investigate the relationship between ethnocentrism and investment in learning English in the multicultural setting of English classrooms at an Iranian medical university. To this end, 200 Iranian medical students’ levels of ethnocentrism and investment in learning English were measured. The findings of this study revealed that the participants had relatively moderate levels of ethnocentrism and investment, and there was a strong negative relationship between the two constructs. Female medical students were found to be significantly less ethnocentric than male students, but were not significantly different from them in terms of investment. These findings were explained considering several contextual factors such as the participants’ linguistic loyalty, intercultural contact, and social comfort in English classrooms. Practical implications, direction, and limitations are discussed.
