This study examined the relationship between cultural intelligence and managers’ performance of travel agencies. The study is applied research in terms of objectives, and this is correlational descriptive research in terms of collecting and analyzing data. The study population consisted of 500 tour managers and guides in Isfahan province. The sampling method was the simple random sampling method, and the sample size was 217 managers and tour guides of the Isfahan according to Cochran`s formula. Data were collected by questionnaire and analyzed by Lisrel software, using structural equation modeling (SEM). Findings show a positive and significant relationship between tour managers' cultural intelligence and their performance in dealing with crises. Thus, the strategic importance of cultural intelligence in managers' performance while dealing with challenges has been approved. Furthermore, cultural intelligence is recognized as one of the factors influencing the prosperity of tourism by enhancing manager performance.
