The beginning of the political crisis in Syria, each regional and trans-regional actors have adopted different policies based on their interests and goals in relation to this country. Syria is an exceptional issue for countries in the region and the world's powers like the United States of America, and any transformation in that form might have a fundamental impact on the interests of each of these regional and global powers. Turkey as a regional power and the United States has always been present in the Syrian crisis as a regional power based on its interests. But the United' support of the present groups in Syria has sought to fight ISIS extremists, which Turkey has called for terrorist groups to reduce the US and Turkey relations. The present study was conducted using descriptive-analytic method and using documentation sources to provide a theoretical framework, the question of why Turkey is against United States about the Syrian Kurdish issue? This study investigates the presence of United States in Syria and the support of Kurdish groups, as well as the reaction that Turkey and Iran have been involved in. The findings of this article indicate that the United States support the Kurdish groups in northern Syria has led to conflict of interest between the two countries.
