This research is conducted aiming to study the relationship of self-directed learning, information technology and communication, and educational motivation with entrepreneur curriculum in distance education. This research is practical, quantitative, and descriptive - correlational (non-experimental) study. Target population of this research included all 550 female students of smart secondary schools in Esfahan city in Academic year of 2016-2017. Using Morgan formula, 225 research samples were selected through clustered sampling method from regions 2, 3, and 5 of Education Administration of Esfahan city. Library and survey methods were used for data collection. The instruments included researcher made questionnaires about entrepreneur curriculum of distant education, educational motivation, self-directed learning, and ICT. The validity of questionnaires was confirmed by ten professors and experts in this field and its reliability was calculated through alpha Cronbach that was 0.73. For analyzing data, SPSS software, version 21, was used to present descriptive and inferential statistic. The results showed that self-directed learning, ICT, and educational motivation have positive significant relationship with entrepreneur curriculum of distance education. It also shows that all of three variables of self- directed learning, ICT, and educational motivation are important in preparing entrepreneur curriculum. Educational motivation have maximum importance with β= 0.43 and information technology has minimum importance with β= 0.23.
