The historic houses of the Qajar era are among the remarkable works of this period, which, due to their close connection with the everyday life of the people, are indicative of the special characteristics of their time. These houses are not only important in terms of plans and architectural spaces, but also unique in terms of decorations and arrays and cultural values. Thus, this paper is aimed at understanding the residential architecture and its design patterns in Qajar houses in Isfahan. The research methodology is analytical and descriptive and has been done with library and field method. Special attention has been paid to the design and spatial designing patterns and by analyzing, analyzing and comparing them, the further categorization of cultural factors and design patterns in Vasigh's home has been provided. Actually, As space organization is considered an integral part of traditional Iranian architecture, In a way, it shows the application of spaces, Also, they represent the dominant thinking of their age. Due to the necessity of his time, the Qajar art faced Western elements and reacted itself selfishly. The result of this response to the design of the architecture is that in many cases the imported elements have been able to combine with the traditional elements. At home, we also encountered spatial patterns that clearly illustrate this issue. At home, we also encountered spatial patterns that clearly illustrate this issue. But in general, artists of this era have been able to achieve unity in the design of the architectural design of this house, despite the combination of elements of different cultures.