Communication is an essential part in languages. It is the purpose of learning a second or a foreign language. Oral communication is one of the aspects that need to be developed among English learners. The study focused on investigating the factors of apprehension among English language students in Palestine. The study aimed to investigate the degree of oral communication apprehension among English senior majors at Al-Quds Open University in Palestine. In order to achieve the study objectives, the researchers used the descriptive approach. Therefore, the study used the Personal Report of Communication Apprehension Measurement (PRCAM) as the main tool of the study. PRCAM was distributed to a sample of 64 English language seniors at Al-Quds Open University in Palestine in Rafah and Khan Younis branches. The major findings of the study revealed that the degree of oral communication apprehension among English senior majors at Al-Quds Open University was moderate and that there was no any statistically significant difference at (a ≤ 0.05) in the oral communication apprehension among English senior majors due to gender (male or female).