Multiple sclerosis affects the quality of life of patients due to its association with numerous neurological problems; it may lead to job loss and reduced participation in social activities and, in general, have a negative impact on their professional and social life. In the present study, the effectiveness of motivational interview group therapy on pain self-efficacy and resilience of patients with multiple sclerosis was investigated. The present study is quasi-experimental in which 24 patients were selected from the population of patients with multiple sclerosis in Borujen city in Chaharmahal and Bakhtiari province, using the available sampling method. Research tools included pain self-efficacy and resilience questionnaires. Data analysis was performed by repeated variance analysis using SPSS-22 software. The results showed that motivational interview group therapy had a significant effect on increasing pain self-efficacy (Partial ŋ2= 0.24, p = 0.002, F = 6.92). Also, motivational interview group therapy had a significant effect on increasing resilience (Partial ŋ2 = 0.58, p = 0.001, F = 30.06). The present study showed that motivational interview group therapy improves pain self-efficacy and resilience of patients with multiple sclerosis. Accordingly, in the process of motivational interview group therapy, patients learn to become aware of the mental process by teaching behavioral, cognitive and metacognitive strategies, and in this way, they improve the resilience and pain self-efficacy.
