This experimental study attempts to see whether incorporating supplemental podcasts into the blended module of second language (L2) vocabulary teaching and learning leads to better learning outcomes in comparison with other common teaching and learning methods as self-study and conventional. To that end, undergraduate students from Ahvaz Jundishapur University of Medical Sciences were summoned up via an announcement to take part in the study. Volunteers were homogenized via Vocabulary Levels Test (VLT) and were then randomly divided into three groups to learn English vocabulary items via three different scenarios during 32 sessions. The collected data from the participants’ answers to the attitude questionnaire and interview as well as the data from assessing their performance throughout the course were analyzed both descriptively and inferentially. The analysis of the data revealed that the podcast-mediated blended L2 learning scenario appeared as the most successful scenario in L2 vocabulary learning. Consequently, it could be concluded that providing miscellaneous practicing opportunities for students would facilitate learning process and contribute to learning improvement.