The relative and long-term stability brought about by the Safavid government in Iran made urbanization and its requirements to be reviewed, next to the issue of public health. Some physicians began to run new experiments and produce treatises. One of these outstanding treatises is the Risala Ateshak, written by Imad al-Din Mahmoud bin Masoud Shirazi. For the first time, by writing an independent treatise, he described the symptoms, methods of prevention, and treatment of syphilis. To him, the treatise issued before his, except that of Baha'u'l-Razi, were not discussed and were considered a phenomenon from abroad (the West). He sought to explain the manners of transmission, prevention, and treatment of this disease in different temperaments through the available methods, which were mostly based on herbal medicine. He also expressed his belief about the effectiveness of consuming Chinese wood in treating this disease. The accuracy of this treatise's contents and its writing period makes it clear that syphilis is not an imported disease contrary to the idea that existed. The reason for our ignorance of its existence was the inability to distinguish it from other diseases.
