In the sixteenth century, the strategic region of the Caucasus had a set of political, economic, transportation, and religious benefits for both the Safavid and Ottoman governments that led the two powers to compete for profound influence and attention in the region. During this period, when some weak and unstable kings such as Ismail II and Muhammad Khudābanda came to power, lack of strength and better performance caused the Ottoman government to grasp the most of the opportunity to extend their influence over the Caucasus. This study aims at investigating the geographical location of the Caucasus considering the Safavid diplomatic policies and the challenges between the Safavids and the Ottoman Empire through analyzing historical data and library studies. Descriptive data analysis has been considered as the method utilized for this research. The research findings indicate that the ineffectiveness of Safavid foreign policy at this time and the consequence of this policy would have an inevitably negative impact on maintaining and controlling the Caucasus. As a result, this policy would provoke the Ottoman invasions, leading to the occupation of some parts of the Caucasus.
